Generative AI for Microfluidic Device Design

Authors

  • Sayed Rafi Basheer Sr. Data and Analytics Analyst in Medical Device Manufacturing. Author

DOI:

https://doi.org/10.63282/3050-9262.IJAIDSML-V7I1P108

Keywords:

Generative AI, Microfluidics, Device Design, Lab-On-A-Chip, Machine Learning, Computational Fluid Dynamics

Abstract

Microfluidic devices enable precise manipulation of fluids at the microscale and are widely used in biomedical diagnostics, drug delivery, and lab-on-a-chip systems. Traditional microfluidic device design relies heavily on iterative simulations and expert-driven trial-and-error processes, which are time-consuming and computationally expensive. Recent advances in generative artificial intelligence offer new opportunities to automate and optimize microfluidic design by learning complex flow patterns and geometries from data. This paper explores the application of generative AI models for microfluidic device design, including variational autoencoders, generative adversarial networks, and diffusion-based models. The study reviews design methodologies, simulation integration, performance evaluation, and emerging research directions. Results indicate that generative AI can significantly reduce design time while improving flow efficiency, mixing performance, and device robustness.

References

[1] G. E. Karniadakis et al., “Physics-informed machine learning,” Nature Reviews Physics, vol. 3, pp. 422–440, 2021.

[2] J. Liu et al., “Deep learning enabled design of microfluidic mixers,” Lab on a Chip, vol. 20, no. 22, pp. 4233–4243, 2020.

[3] Goodfellow et al., “Generative adversarial networks,” Communications of the ACM, vol. 63, no. 11, pp. 139–144, 2020.

[4] D. P. Kingma and M. Welling, “Auto-encoding variational Bayes,” International Conference on Learning Representations, 2014.

[5] J. Ho et al., “Denoising diffusion probabilistic models,” Advances in Neural Information Processing Systems, 2020.

Published

2026-01-23

Issue

Section

Articles

How to Cite

1.
Rafi Basheer S. Generative AI for Microfluidic Device Design. IJAIDSML [Internet]. 2026 Jan. 23 [cited 2026 Jan. 23];7(1):34-8. Available from: https://ijaidsml.org/index.php/ijaidsml/article/view/401