AI-Optimized Symmetry Episode Analytics for Early Detection of High-Utilizers: A Claims-Based Predictive Modelling Framework Using Advanced Machine Learning Models

Authors

  • Mani Kanta Pothuri Independent researcher, USA. Author

DOI:

https://doi.org/10.63282/3050-9262.IJAIDSML-V7I1P147

Keywords:

Symmetry episode analytics, AI, ML, Cyber issues, Population health, Persistent threat, High utilizers, ETG(Episode Treatment Groups), ERG (Episode Risk Groups), PEG(procedure-based analytics groups

Abstract

The continuously increasing medical expenses are now considered as priority for national economy and organizational finance management for strategic emphasis on finances. The increasing concern about economic risks and compounded influence on population health needs to be managed suitably.  Managing issues like increasing costs and staff limitations, along with cyber issues require insightful analysis. Perceptions regarding the continuously changing healthcare challenge is critical for supporting claim processing with compliance and effective care. Supporting patients with high-quality healthcare emphasizes on persistent threats. They require practical processes to support in managing associated complexities. Increasing the strength of healthcare claim management and risk handling requires using strategies to manage the challenges. This study involves development of a predictive modeling structure and framework, unifying symmetry episode analytics and ETG/ERG/PEG with supervised learning models.  These models enhance the strength to manage compliance and address shrinking margins according to revenue generated. The paper discusses information regarding Symmetry episode analytics combination with intelligence (AI) and learning (ML), for effective therapy delivery and cost reduction. The outcomes involve demonstration of AI-streamlined episode analytics for identification of high-utilizers proactively and empower healthcare management for targeted interventions therapeutically.

References

[1] R&I Editorial Team, "Global Medical Costs to Rise 9.8% in 2026, Returning to Single-Digit Growth," R&I, 13 October 2025. [Online]. Available: http://riskandinsurance.com/global-medical-costs-to-rise-9-8-in-2026-returning-to-single-digit-growth/. [Accessed 19 December 2025].

[2] R. Abeysinghe, A. Black, D. Kaduk, Y. Li, C. Reich, A. Davydov, L. Yao and L. Cui, "Towards quality improvement of vaccine concept mappings in the OMOP vocabulary with a semi-automated method," Journal of Biomedical Informatics, vol. 134, no. 1, pp. 1-8, 2022.

[3] Al-Nafjan, A. Aljuhani, A. Alshebel, A. Alharbi and A. Alshehri, "Artificial Intelligence in Predictive Healthcare: A Systematic Review," J. Clin. Med, vol. 14, no. 19, pp. 1-17, 2025.

[4] L. Beam and I. S. Kohane, "Big Data and Machine Learning in Health Care," JAMA, vol. 319, no. 13, pp. 1317-1318, 2018.

[5] M. N. A. Bhuiyan and R. S. Mondal, "AI-Driven Predictive Analytics in Healthcare: Evaluating Impact on Cost and Efficiency," Journal of Computational Analysis and Applications (JoCAAA), vol. 31, no. 4, p. 1355–1371, 2023.

[6] J. K. Tan, L. Quan, N. N. M. Salim, T. J. H, G. S. Y, T. J and B. Y. M, "Machine-learning based prediction for high health care utilizers using a multi-institution registry," European Journal of Public Health, vol. 34, no. 3, pp. 1-22, 2024.

[7] N. Nghiem, J. Atkinson, B. P. Nguyen, A. Tran-Duy and N. Wilson, "Predicting high health-cost users among people with cardiovascular disease using machine learning and nationwide linked social administrative datasets," Health Economics Review, vol. 13, no. 9, pp. 1-13, 2023.

[8] G. Barenboim, J. Hirn and V. Sanz, "Symmetry meets AI," SciPost Physics, vol. 11, no. 014, pp. 1-10, 2021.

[9] D. Ravì, C. Wong, F. Deligianni, M. Berthelot, J. Andreu-Perez and B. Lo, "Deep Learning for Health Informatics," IEEE Journal of Biomedical and Health Informatics, vol. 21, no. 1, pp. 4-21, 2017.

[10] X. Zhang, H. Wu, T. Chen and G. Wang, "Automatic diagnosis of arrhythmia with electrocardiogram using multiple instance learning: From rhythm annotation to heartbeat prediction," Artificial Intelligence in Medicine, vol. 132, no. 1, pp. 1-12, 2022.

[11] M. L. Burns, S.-Y. Chen, C.-A. Tsai, J. Vandervest, B. Pandian, P. Nong, D. A. Hanauer, A. Rosenberg and J. Platt, "Generative AI costs in large healthcare systems, an example in revenue cycle," npj Digital Medicine, vol. 8, no. 579, pp. 1-5, 2025.

[12] H. Javed, S. El-Sappagh and T. Abuhmed, "Robustness in deep learning models for medical diagnostics: security and adversarial challenges towards robust AI applications," 2025, vol. 58, no. 12, pp. 1-107, 2025.

[13] J. Keck, C. Barry, C. Doeller and J. Jost, "Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation," PLOS Computational Biology, vol. 2025, no. 1, pp. 1-10, 2025.

[14] Holzinger, G. Langs, H. Denk, K. Zatloukal and H. Müller, "Causability and explainability of artificial intelligence in medicine," WIREs Data Mining and Knowledge Discovery, vol. 9, no. 4, pp. 1-20, 2019.

[15] Optum, "Symmetry Episode Risk Groups (ERG)," Optum, Inc, USA, 2022.

[16] S. Guleria, J. Guptill, I. Kumar, M. McClintic and J. C. Rojas, "Artificial intelligence integration in healthcare: perspectives and trends in a survey of U.S. health system leaders," BMC Digital Health, vol. 2, no. 80, pp. 1-8, 2024.

[17] L. I. Weil, L. R. Zwerwer, H. Chu, M. Verhoeff, P. P. Jeurissen and B. C. v. Munster, "Identifying future high healthcare utilization in patients with multimorbidity – development and internal validation of machine learning prediction models using electronic health record data," Health and Technology, vol. 14, no. 1, p. 433–449, 2024.

[18] A. Kunle and K. A. Taiwo, "Predictive Modeling for Healthcare Cost Analysis in the United States: A Comprehensive Review and Future Directions," International Journal of Scientific Research and Modern Technology, vol. 4, no. 1, p. 170–181, 2025.

[19] K. Lynch, B. Viernes, E. Gatsby, S. Knight, S. DuVall and J. Blosnich, "All-Cause and Suicide Mortality Among Lesbian, Gay, and Bisexual Veterans Who Utilize Care through the Veterans Health Administration," Health Services Research, vol. 55, no. S1, pp. 53-54, 2020.

[20] Y. Ma, X. Tu, X. Luo, L. Hu and C. Wang, "Machine-learning-based cost prediction models for inpatients with mental disorders in China," BMC Psychiatry, vol. 25, no. 33, pp. 1-16, 2025.

[21] D. S. Mack, J. Baek, J. Tjia and K. L. Lapane, "Geographic Variation of Statin Use Among US Nursing Home Residents With Life-limiting Illness," Medical Care, vol. 59, no. 5, pp. 425-436, 2021..

[22] A. Mateen, J. Liley, A. K. Denniston, C. C. Holmes and S. J. Vollmer, "Improving the quality of machine learning in health applications and clinical research," Nature Machine Intelligence, vol. 2, no. 1, p. 554–556, 2020.

[23] Z. Obermeyer, B. Powers, C. Vogeli and S. Mullainathan, "Dissecting racial bias in an algorithm used to manage the health of populations," Science, vol. 366, no. 6464, pp. 447-453, 2019.

[24] Higgins, S. Racaniere and D. Rezende, "Symmetry-Based Representations for Artificial and Biological General Intelligence," Frontiers of Computing Neurosciences, vol. 16, no. 1, pp. 1-10, 2022.

[25] E. J. Topol, "High-performance medicine: the convergence of human and artificial intelligence," Nature Medicine, vol. 25, no. 1, p. 44–56, 2019.

[26] E. A. Seyam, "Predicting High-Cost Healthcare Utilization Using Machine Learning: A Multi-Service Risk Stratification Analysis in EU-Based Private Group Health Insurance," Risks, vol. 13, no. 7, pp. 1-19, 2025.

[27] R. Shalinirajan, S. S, V. Prithivirajan, S. D, P. Kurada and R. P, "Transforming Healthcare: AI Models for Predictive Analysis in Medical Applications," 4th Asian Conference on Innovation in Technology (ASIANCON), vol. 1, no. 1, pp. 1-6, 2024.

[28] E. H. Shortliffe and M. J. Sepúlveda, "Clinical Decision Support in the Era of Artificial Intelligence," JAMA, vol. 320, no. 21, pp. 2199-2200, 2018.

[29] Tae, H. Kong, J. Lee and Y. Lee, "Machine learning for disease-specific prediction of high-cost patients," Engineering Applications of Artificial Intelligence, vol. 161 C, no. 1, pp. 1-29, 2025.

[30] W. N. Price and I. G. Cohen, "Privacy in the age of medical big data," Nature Medicine, vol. 25, no. 1, p. 37–43, 2019.

[31] Y. Rahman and P. Dua, "A machine learning framework for predicting healthcare utilization and risk factors," Healthcare Analytics, vol. 8, no. 1, pp. 1-20, 2025.

[32] Rajkomar, J. Dean and I. Kohane, "Machine Learning in Medicine," N Engl J Med, vol. 380, no. 14, pp. 1347-1358, 2019.

[33] S. Ramesh, L. Shanmugam and S. Ramalingam, "Predictive Analytics for Healthcare Cost Control: Using AI/ML to Forecast Expenses and Manage Financial Sustainability," Journal of Artificial Intelligence Research, vol. 2, no. 1, pp. 306-346, 2022.

[34] R. Rao, R. Jain, M. Singh and R. Garg, "Predictive interpretable analytics models for forecasting healthcare costs using open healthcare data," Healthcare Analytics, vol. 6, no. 1, pp. 1-20, 2024.

Published

2026-03-06

Issue

Section

Articles

How to Cite

1.
Pothuri MK. AI-Optimized Symmetry Episode Analytics for Early Detection of High-Utilizers: A Claims-Based Predictive Modelling Framework Using Advanced Machine Learning Models. IJAIDSML [Internet]. 2026 Mar. 6 [cited 2026 Mar. 13];7(1):279-87. Available from: https://ijaidsml.org/index.php/ijaidsml/article/view/473